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In particular, pretreatment with the GHSR1a inverse agonist SP-analog results in cross-sensitization to the 5-HT 2C response in cells coexpressing GHSR1a and 5-HT 2C (Schellekens et al., 2013)
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This can be performed with the assistance of NO-system, given that in apomorphine or amphetamine (acute application) and methamphetamine (chronic application) rats, BPC 157 therapy counteracts the effects of NO-agents application [70]
These considerations are particularly relevant in Australian climate conditions where shipping distances can impact cold-chain integrity
