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Definition of the role of melatonin in the patho-physiological mechanisms of inflammation has also been a growing research field

Many genes or molecules have been identified to play pivotal roles in the regulation of APAP hepatotoxicity, so they are suggested to be potential targets for therapeutic intervention against APAP-induced liver injury

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In vivo pharmacokinetic measurements The pharmacokinetic assessment was conducted using a total of eight male DIO C57BL/6J mice ( n = 4 per subgroup)