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Moreover, L-carnitine counteracted the inhibitory action of lenvatinib on global protein synthesis in C2C12 myocytes, the major mechanism considered for preventive effect of L-carnitine against lenvatinib-induced muscle toxicity
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The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors
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