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coli SAM synthetase to reduce product inhibition and increase catalytic activity is a complementary strategy ( The L-carnitine biosensor fluorescence signal suggested high conversion of L-carnitine from intracellular TML (Figure 5B) as values were comparable to direct L-carnitine supplementation (Figure 6B), suggesting that the biosensor is sensitive to low intracellular L-carnitine levels and that the export of L-carnitine out of the E

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