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Description
The monomer was mainly accumulated in the necrotic core and around macrophages, T cells, and SMC clusters, as well as neovessels in atherosclerotic plaques
In one study, repeated topical 5% DHA application in hairless dogs led to irritant contact dermatitis, with histopathological findings of epidermal thickening, degeneration, and inflammatory changes, while vehicle-only controls showed no such effects, indicating DHA as the causative agent
A clinicopathologic study of 268 cases
This is more likely with higher or sustained doses and is usually reversible once therapy is discontinued
