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SARS-CoV-2 ACE2-mediated host cell invasion is enhanced by the presence of heparan sulfate proteoglycans (HSPGs) consisting of a core protein bearing glycosaminoglycan carbohydrate chains (Souza-Fernandes et al., 2006

There are various types of mutations, including deletion, RNA-processing defects, translation, and missense mutations, which may affect every step essential for the correct functioning of the pathway, from ligand binding to signal transduction, and which finally determine the failure to stimulate normal growth (22)

Megaloblastic anemia can be caused by a deficiency of B12, B9, or both

Whatever the case, we infer that inhibiting TCA activity actually protects ER homeostasis in part because of its effects on ER ultrastructure