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Studies have found that the downregulation of OPA1 will induce mitochondrial fragmentation and cellular apoptosis (Ni et al., 2017)

Such acetylation homeostasis is determined by the interplay between two classes of antagonistic enzymes, histone acetyltransferases (HATs) and histone deacetylases (HDACs), which transfer or remove, respectively, an acetyl moiety of a lysine residue mapping in the N-terminal tail of nucleosomal histones 7
474,475,476 Regarding novel lactate/lactylation inhibitors, PROTAC are novel small-molecule inhibitors that downregulate or even eliminate their target proteins via the ubiquitin-proteasome pathway
