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Chronic antigen stimulation and persistent TCR signaling upregulate death receptors such as Fas (CD95) and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors on activated T cells, increasing their susceptibility to activation-induced cell death (AICD) [304]

Similarly, the epidermal growth factor receptor (EGFR)-targeted osimertinib demonstrates an ORR of up to 80% [2], while human epidermal growth factor receptor- 2 (HER- 2)-targeted trastuzumab deruxtecan yields over 50% ORR in patients of HER- 2 -amplified breast cancer with brain metastases [3]