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Similarly, the quinolinium containing parent analogue 1-MQ also lacked passive diffusion properties (Table 1), suggesting that the lipophilicity and drug-like permeability properties of analogues within the methylquinolinium series had to be improved via chemical modification

A four-week initiation block therefore contains just four injections, all on the same weekday, and the whole block sits at 2.5 mg before the first escalation is even considered

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