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Reactive oxygen Species (Ros) homeostasis and redox regulation in cellular signaling

CCK-8 (Dojindo Laboratories, Inc.) was used to detect the viability of cells

Chronic painand several pain medicationsdisrupt normal sleep architecture, reducing slow-wave and restorative sleep phases

The binding of Nrf2 to AREs is controlled by the small Maf proteins (MafG, MafK, and MafF), which form heterodimers with Nrf2, effective in the activation of AREs, but at the same time, Maf proteins can homodimerize with each other, preventing the activation of AREs by Nrf2 [193,194]
