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reported that paricalcitol modulates the Angiopoietin-2/VEGF/VEGFR2 axis, attenuates TGF- related signaling, and preserves renal tissue architecture in an adriamycin nephropathy model (37)

Compared to the liver, we observed that the kidney has: (1) similar increased use of energy-related metabolites and production of urea cycle and ammonia-related intermediates, suggesting a shared catabolism in AKI, and (2) higher pools of energy metabolism intermediates in AKI

The pharmacological effects of metformin have been shown to target the insulin-like growth factor (IGF), AMP-activated protein kinase (AMPK), phosphatidylinositol 3-kinase (PI3K)/AKT, MAPK, NF-B, and other signal transduction pathways, highlighting its potential in the treatment of gynecological disorders

However, the safety of amantadine remains controversial and warrants further investigation