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Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

Di Domenico F, Tramutola A, Foppoli C, Head E, Perluigi M, Butterfield DA (2018) mTOR in Down syndrome: role in A and tau neuropathology and transition to Alzheimer disease-like dementia

This suggests that targeted therapy aimed at Gln metabolism may represent a novel and potentially effective strategy for cancer patients