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10.3390/catal10101114

MDHAR4 mutants also have lower ascorbate to DHA ratios, but have similar total ascorbate levels to the wild type (Eastmond, 2007)

NAD depletion from poly (ADP-ribose) polymerase-1 (PARP-1) hyperactivation further impairs SIRT function, mitochondrial biosynthesis, and antioxidant defenses [71, 72]

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